RGD Reference Report - A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover. - Rat Genome Database

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A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover.

Authors: Satomi, S  Yamasaki, Y  Tsuzuki, S  Hitomi, Y  Iwanaga, T  Fushiki, T 
Citation: Satomi S, etal., Biochem Biophys Res Commun 2001 Oct 5;287(4):995-1002.
RGD ID: 634217
Pubmed: PMID:11573963   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.5686   (Journal Full-text)

Membrane type-serine protease 1 (MT-SP1) plays potential roles in the process of invasion and metastasis of carcinomas. In the present study, we cloned a rat MT-SP1 cDNA and investigated the intestinal distribution and proteolytic properties of the enzyme. By in situ hybridization we found the prominent expression of the mRNA in the epithelial layer of the small intestinal upper villi and of the colon, where cells are loosely attached to the basement membrane. When MT-SP1 was expressed in Caco-2, a colonic carcinoma cell line, the protein was localized exclusively on the basolateral side. A secreted form of the enzyme produced in COS-1 cells digested fibronectin and laminin. These findings suggest that MT-SP1 participates in the control of intestinal epithelial turnover by regulating the cell-substratum adhesion.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein catabolic process  IDA 634217 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
serine-type peptidase activity  IDA 634217 RGD 

Objects Annotated

Genes (Rattus norvegicus)
St14  (ST14 transmembrane serine protease matriptase)


Additional Information