RGD Reference Report - Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission. - Rat Genome Database

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Molecular analysis of system N suggests novel physiological roles in nitrogen metabolism and synaptic transmission.

Authors: Chaudhry, FA  Reimer, RJ  Krizaj, D  Barber, D  Storm-Mathisen, J  Copenhagen, DR  Edwards, RH 
Citation: Chaudhry FA, etal., Cell 1999 Dec 23;99(7):769-80.
RGD ID: 634178
Pubmed: (View Article at PubMed) PMID:10619430

The amino acid glutamine has a central role in nitrogen metabolism. Although the molecular mechanisms responsible for its transport across cell membranes remain poorly understood, classical amino acid transport system N appears particularly important. Using intracellular pH measurements, we have now identified an orphan protein related to a vesicular neurotransmitter transporter as system N. Functional analysis shows that this protein (SN1) involves H+ exchange as well as Na+ cotransport and, under physiological conditions, mediates glutamine efflux as well as uptake. Together with the pattern of SN1 expression, these unusual properties suggest novel physiological roles for system N in nitrogen metabolism and synaptic transmission.

Annotation

Gene Ontology Annotations    

Biological Process

Cellular Component

Objects Annotated

Genes (Rattus norvegicus)
Slc38a3  (solute carrier family 38, member 3)

Objects referenced in this article
0 SLC38A3 solute carrier family 38 member 3 All species

Additional Information