RGD Reference Report - On the cDNA's for two types of rat pancreatic secretory trypsin inhibitor. - Rat Genome Database

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On the cDNA's for two types of rat pancreatic secretory trypsin inhibitor.

Authors: Horii, A  Tomita, N  Yokouchi, H  Doi, S  Uda, K  Ogawa, M  Mori, T  Matsubara, K 
Citation: Horii A, etal., Biochem Biophys Res Commun 1989 Jul 14;162(1):151-9.
RGD ID: 634099
Pubmed: PMID:2751646   (View Abstract at PubMed)

Two types of cDNA, which code for the two types of rat pancreatic secretory trypsin inhibitors (PSTIs), were cloned and sequenced. Both predicted amino acid sequences consisting of 79 amino acids, with the secretion signal peptide consisting of 18 and 23 amino acids for PSTI-I and PSTI-II, respectively. The nucleotide sequences were 91% homologous between the two cDNAs, but 68% and 65% homologous, respectively, when compared with human PSTI cDNA. Northern blot analyses showed that PSTI-I is expressed in the pancreas, whereas PSTI-II is expressed in the pancreas and the liver using the same promoter. Southern blot analyses suggested that both PSTI-I and PSTI-II genes are single copy genes per haploid genome. Duplication of rat PSTI gene seems to have occurred recently, after the divergence of humans and rats.



Objects referenced in this article
Gene Spink1 serine peptidase inhibitor, Kazal type 1 Rattus norvegicus
Gene Spink1l serine peptidase inhibitor, Kazal type 1-like Rattus norvegicus

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