RGD Reference Report - Trace amines: identification of a family of mammalian G protein-coupled receptors. - Rat Genome Database

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Trace amines: identification of a family of mammalian G protein-coupled receptors.

Authors: Borowsky, B  Adham, N  Jones, KA  Raddatz, R  Artymyshyn, R  Ogozalek, KL  Durkin, MM  Lakhlani, PP  Bonini, JA  Pathirana, S  Boyle, N  Pu, X  Kouranova, E  Lichtblau, H  Ochoa, FY  Branchek, TA  Gerald, C 
Citation: Borowsky B, etal., Proc Natl Acad Sci U S A 2001 Jul 31;98(16):8966-71.
RGD ID: 634071
Pubmed: PMID:11459929   (View Abstract at PubMed)
PMCID: PMC55357   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.151105198   (Journal Full-text)

Tyramine, beta-phenylethylamine, tryptamine, and octopamine are biogenic amines present in trace levels in mammalian nervous systems. Although some "trace amines" have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Using a degenerate PCR approach, we have identified 15 G protein-coupled receptors (GPCR) from human and rodent tissues. Together with the orphan receptor PNR, these receptors form a subfamily of rhodopsin GPCRs distinct from, but related to the classical biogenic amine receptors. We have demonstrated that two of these receptors bind and/or are activated by trace amines. The cloning of mammalian GPCRs for trace amines supports a role for trace amines as neurotransmitters in vertebrates. Three of the four human receptors from this family are present in the amygdala, possibly linking trace amine receptors to affective disorders. The identification of this family of receptors should rekindle the investigation of the roles of trace amines in mammalian nervous systems and may potentially lead to the development of novel therapeutics for a variety of indications.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Taar4Rattrace-amine receptor activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Taar4  (trace amine-associated receptor 4)

Objects referenced in this article
Gene TAAR1 trace amine associated receptor 1 Homo sapiens
Gene TAAR6 trace amine associated receptor 6 Homo sapiens
Gene TAAR8 trace amine associated receptor 8 Homo sapiens
Gene Taar1 trace amine-associated receptor 1 Mus musculus
Gene Taar6 trace amine-associated receptor 6 Rattus norvegicus
Gene Taar7a trace amine-associated receptor 7a Rattus norvegicus
Gene Taar7b trace amine-associated receptor 7b Rattus norvegicus
Gene Taar7d trace-amine-associated receptor 7d Rattus norvegicus
Gene Taar7e trace-amine-associated receptor 7e Rattus norvegicus
Gene Taar7f-ps trace amine-associated receptor 7f, pseudogene Rattus norvegicus
Gene Taar7g trace amine-associated receptor 7g Rattus norvegicus
Gene Taar7h trace amine-associated receptor 7h Rattus norvegicus
Gene Taar8a trace amine associated receptor 8A Rattus norvegicus
Gene Taar8b trace amine-associated receptor 8B Rattus norvegicus
Gene Taar8c trace amine-associated receptor 8C Rattus norvegicus
Gene Taar9 trace amine-associated receptor 9 Rattus norvegicus

Additional Information