RGD Reference Report - beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. - Rat Genome Database

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beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics.

Authors: Morgan, K  Stevens, EB  Shah, B  Cox, PJ  Dixon, AK  Lee, K  Pinnock, RD  Hughes, J  Richardson, PJ  Mizuguchi, K  Jackson, AP 
Citation: Morgan K, etal., Proc Natl Acad Sci U S A 2000 Feb 29;97(5):2308-13.
RGD ID: 633985
Pubmed: PMID:10688874   (View Abstract at PubMed)
PMCID: PMC15797   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.030362197   (Journal Full-text)

The voltage-sensitive sodium channel confers electrical excitability on neurons, a fundamental property required for higher processes including cognition. The ion-conducting alpha-subunit of the channel is regulated by two known auxiliary subunits, beta1 and beta2. We have identified rat and human forms of an additional subunit, beta3. It is most closely related to beta1 and is the product of a separate gene localized to human chromosome 11q23.3. When expressed in Xenopus oocytes, beta3 inactivates sodium channel opening more slowly than beta1 does. Structural modeling has identified an amino acid residue in the putative alpha-subunit binding site of beta3 that may play a role in this difference. The expression of beta3 within the central nervous system differs significantly from beta1. Our results strongly suggest that beta3 performs a distinct neurophysiological function.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
sodium ion transport  IDA 633985 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Scn3b  (sodium voltage-gated channel beta subunit 3)

Objects referenced in this article
Gene SCN3B sodium voltage-gated channel beta subunit 3 Homo sapiens

Additional Information