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SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus.

Authors: Shimizu, K  Okada, M  Takano, A  Nagai, K 
Citation: Shimizu K, etal., FEBS Lett 1999 Sep 24;458(3):363-9.
Pubmed: (View Article at PubMed) PMID:10570941

To elucidate the mechanism of the circadian rhythm, genes differentially expressed during subjective day and night in the rat suprachiasmatic nucleus (SCN), a circadian oscillator in mammals, were surveyed by a differential display method. We isolated a novel gene, scop (SCN circadian oscillatory protein), that was expressed in a circadian manner in the SCN. SCOP protein is predominantly expressed in the brain and has domains including a pleckstrin homology domain, leucine-rich repeats, a protein phosphatase 2C-like domain and a glutamine-rich region. The structural feature of SCOP protein suggests its role in the intracellular signaling in the SCN.


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RGD Object Information
RGD ID: 633914
Created: 2003-08-29
Species: All species
Last Modified: 2003-08-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.