RGD Reference Report - Identification of four new members of the rat prolactin/growth hormone gene family. - Rat Genome Database

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Identification of four new members of the rat prolactin/growth hormone gene family.

Authors: Ishibashi, K  Imai, M 
Citation: Ishibashi K and Imai M, Biochem Biophys Res Commun 1999 Sep 7;262(3):575-8.
RGD ID: 633805
Pubmed: PMID:10471365   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1999.1260   (Journal Full-text)

The rodent prolactin (PRL)/growth hormone (GH) gene family currently consists of at least 14 distinct genes that are expressed mainly in pituitary, uterus, and/or placenta. We report here the identification of novel four members from rat with significant homology to PRL. The encoding proteins are not homologs of other known members of this hormone family. The four new cDNAs were assigned to PRL family based on sequence homology and were referred to as PRL-like protein-I (PLP-I), PLP-J, PLP-K, and PLP-L, following the current naming order of rodent PLP family, where PLP-H is the most recent gene. They encode amino acids with 211-228 amino acids, and 34-38% identity with PRL. All have one or two N-linked glycosylation sites. Among the examined rat tissues by Northern blot analysis, only PLP-I was expressed in testis. Our results indicate that the rodent PRL/GH gene family is large with at least 18 distinct genes.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Prl2b1Rathormone activity  TAS  RGD 
Prl3c1Rathormone activity  TAS  RGD 
Prl5a1Rathormone activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prl2b1  (prolactin family 2, subfamily B, member 1)
Prl3c1  (prolactin family 3, subfamily C, member 1)
Prl5a1  (prolactin family 5, subfamily A, member 1)

Objects referenced in this article
Gene Prl3a1 prolactin family 3, subfamily A, member 1 Rattus norvegicus

Additional Information