RGD Reference Report - The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates. - Rat Genome Database

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The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates.

Authors: Hazkani-Covo, E  Altman, N  Horowitz, M  Graur, D 
Citation: Hazkani-Covo E, etal., J Mol Evol 2002 Jan;54(1):30-4.
RGD ID: 633776
Pubmed: PMID:11734895   (View Abstract at PubMed)
DOI: DOI:10.1007/s00239-001-0014-0   (Journal Full-text)

Prosaposin is a multifunctional protein encoded by a single-copy gene. It contains four saposin domains (A, B, C, and D) occurring as tandem repeats connected by linker sequences. Because the saposin domains are similar to one another, it is deduced that they were created by sequential duplications of an ancestral domain. There are two types of evolutionary scenarios that may explain the creation of the four-domain gene: (1) two rounds of tandem internal gene duplication and (2) three rounds of duplications. An evolutionary and phylogenetic analysis of saposin DNA and amino acid sequences from human, mouse, rat, chicken, and zebrafish indicates that the first evolutionary scenario is the most likely. Accordingly, an ancestral saposin-unit duplication produced a two-domain gene, which, subsequently, underwent a second complete tandem duplication to give rise to the present four-domain structure of the prosaposin gene.

Objects referenced in this article
Gene Psap prosaposin Rattus norvegicus

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