RGD Reference Report - Expression screening reveals an orphan receptor chick ovalbumin upstream promoter transcription factor I as a regulator of neurite/substrate-cell contacts and cell aggregation. - Rat Genome Database

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Expression screening reveals an orphan receptor chick ovalbumin upstream promoter transcription factor I as a regulator of neurite/substrate-cell contacts and cell aggregation.

Authors: Connor, H  Nornes, H  Neuman, T 
Citation: Connor H, etal., J Biol Chem 1995 Jun 23;270(25):15066-70.
RGD ID: 633499
Pubmed: PMID:7797489   (View Abstract at PubMed)

A rat homologue of chick ovalbumin upstream promoter transcription factor I (COUP-TF I) was isolated using an expression cloning method developed to isolate neurite outgrowth inhibitors. Overexpression of COUP-TF I in 3T3 fibroblasts resulted in reduction of stable contact formation between neurites and transfected cells. Additionally, COUP-TF I enhanced retinoic acid response element-dependent reporter gene expression in 3T3 fibroblasts, indicating that COUP-TF I can modulate transcriptional activation in these cells. Our data suggest that COUP-TF transcription factors are involved in the regulation of cell surface molecules during neruogenesis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
retinoic acid-responsive element binding  IDA 633499 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nr2f1  (nuclear receptor subfamily 2, group F, member 1)


Additional Information