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Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions.

Authors: Irie, M  Hata, Y  Deguchi, M  Ide, N  Hirao, K  Yao, I  Nishioka, H  Takai, Y 
Citation: Irie M, etal., Oncogene 1999 May 6;18(18):2811-7.
Pubmed: (View Article at PubMed) PMID:10362251
DOI: Full-text: DOI:10.1038/sj.onc.1202652

In Caenorhabditis elegans, the vulval induction is mediated by the let-23 receptor tyrosine kinase (RTK)/ Ras signaling pathway. The precise localization of the let-23 RTK at the epithelial junctions is essential for the vulval induction, and requires three genes including lin-2, -7, and -10. The mammalian homologue of lin-2 has been identified as a protein interacting with a neuronal adhesion molecule, neurexin, and named CASK. CASK has recently been reported to interact with syndecans and an actin-binding protein, band 4.1, at epithelial and synaptic junctions, and to play central roles in the formation of cell-cell junctions. The product of C. elegans lin-7 directly interacts with let-23 RTK and localize it at epithelial junctions. Here, we report three rat homologues of lin-7 ubiquitously expressed in various tissues. These homologues are accumulated at the junctional complex region in cultured Madin-Darby canine kidney cells, and are also localized at the synaptic junctions in neurons. The mammalian homologues of lin-7 may be implicated in the formation of cell-cell junctions.


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RGD Object Information
RGD ID: 633233
Created: 2003-08-29
Species: All species
Last Modified: 2004-05-25
Status: ACTIVE


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