RGD Reference Report - GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. - Rat Genome Database

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GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex.

Authors: Ye, B  Liao, D  Zhang, X  Zhang, P  Dong, H  Huganir, RL 
Citation: Ye B, etal., Neuron 2000 Jun;26(3):603-17.
RGD ID: 632892
Pubmed: PMID:10896157   (View Abstract at PubMed)

The PDZ domain-containing proteins, such as PSD-95 and GRIP, have been suggested to be involved in the targeting of glutamate receptors, a process that plays a critical role in the efficiency of synaptic transmission and plasticity. To address the molecular mechanisms underlying AMPA receptor synaptic localization, we have identified several GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Overexpression of GRASP-1 in cultured neurons specifically reduced the synaptic targeting of AMPA receptors. In addition, the subcellular distribution of both AMPA receptors and GRASP-1 was rapidly regulated by the activation of NMDA receptors. These results suggest that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of protein localization  IMP 632892 RGD 
negative regulation of receptor clustering  IMP 632892 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendrite  IDA 632892MMO:0000538RGD 
neuronal cell body  IDA 632892MMO:0000538RGD 
presynaptic membrane  IDA 632892MMO:0000679RGD 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Gria2  (glutamate ionotropic receptor AMPA type subunit 2)
Grip1  (glutamate receptor interacting protein 1)
Grip2  (glutamate receptor interacting protein 2)
Gripap1  (GRIP1 associated protein 1)

Objects referenced in this article
Gene GRIPAP1 GRIP1 associated protein 1 Homo sapiens

Additional Information