RGD Reference Report - Two membrane forms of guanylyl cyclase found in the eye. - Rat Genome Database

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Two membrane forms of guanylyl cyclase found in the eye.

Authors: Yang, RB  Foster, DC  Garbers, DL  Fulle, HJ 
Citation: Yang RB, etal., Proc Natl Acad Sci U S A 1995 Jan 17;92(2):602-6.
RGD ID: 632891
Pubmed: PMID:7831337   (View Abstract at PubMed)
PMCID: PMC42790   (View Article at PubMed Central)

The cDNAs for two membrane guanylyl cyclases, designated E (GC-E) and F (GC-F, were isolated from a rat eye cDNA library. Their deduced topographic structures correspond to known members of the guanylyl cyclase receptor family, containing an extracellular domain, a single membrane-spanning domain, a protein kinase-like domain, and a cyclase catalytic domain. GC-E was expressed in the eye and the pineal gland, whereas GC-F expression was confined to the eye. Overproduction of GC-E and GC-F in COS cells resulted in expression of guanylyl cyclase activity, but ligands known to activate other guanylyl cyclase receptors failed to stimulate enzyme activity. Thus, both GC-E and GC-F remain orphan receptors. Amino acid sequence similarity between GC-E and GC-F in the extracellular region and homology with a cyclase expressed in olfactory neurons and retGC, a rod outer-segment-specific cyclase, suggest that there is another subfamily of guanylyl cyclase receptors, possibly restricted to sensory tissues.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
plasma membrane located_inIDA 632891PMID:7831337UniProt 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
guanylate cyclase activity  IDA 632891; 632891 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gucy2d  (guanylate cyclase 2D, retinal)
Gucy2f  (guanylate cyclase 2F)


Additional Information