RGD Reference Report - The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5. - Rat Genome Database

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The rat FGF-5 mRNA variant generated by alternative splicing encodes a novel truncated form of FGF-5.

Authors: Hattori, Y  Yamasaki, M  Itoh, N 
Citation: Hattori Y, etal., Biochim Biophys Acta 1996 Apr 10;1306(1):31-3.
RGD ID: 632714
Pubmed: PMID:8611621   (View Abstract at PubMed)

We isolated rat FGF-5 cDNA and its variant from the embryo. The FGF-5 cDNA encodes a protein of 266 amino acid residues. The variant cDNA encodes a protein of 121 amino acid residues, the N-terminal 117-amino acid sequence of which is identical to that of FGF-5. Thus the variant cDNA encodes a novel truncated form of FGF-5. The rat FGF-5 gene consists of three exons (exons 1-3). The variant cDNA lacks the nucleotide sequence of exon 2, indicating that the variant mRNA is generated by alternative splicing. The variant mRNA as well as the FGF-5 mRNA was detected in the embryo and adult brain. This is the first description of the mRNA for a truncated form of FGF within the FGF family.

Objects referenced in this article
Gene Fgf5 fibroblast growth factor 5 Rattus norvegicus

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