RGD Reference Report - CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity. - Rat Genome Database

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CaBP2 is a rat homolog of ERp72 with proteindisulfide isomerase activity.

Authors: Van, PN  Rupp, K  Lampen, A  Soling, HD 
Citation: Van PN, etal., Eur J Biochem 1993 Apr 15;213(2):789-95.
RGD ID: 632673
Pubmed: PMID:8477750   (View Abstract at PubMed)

Ca-binding protein 2 (CaBP2) has been described previously as an intracisternal calcium-binding microsomal glycoprotein. We report now the primary sequence of this protein as deduced from the corresponding cDNA. The protein possesses a C-terminal -KEEL retention sequence and three repeats of the thioredoxin-like motive -EFYAPNCGHCK-, and represents the rat homolog of ERp72. In contrast to earlier reports on ERp72, CaBP2 possesses significant proteindisulfide isomerase activity. Furthermore, in contrast to ERp72, CaBP2 is a glycoporotein containing O-linked glycans. The amount of CaBP2 in H-35 Reuber hepatoma cells increases in parallel with that of immunoglobin heavy-chain-binding protein under conditions which lead to impaired glycosylation, while the amount of calreticulin, another KDEL-containing glycoprotein, remains almost unchanged.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pdia4Ratprotein disulfide isomerase activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdia4  (protein disulfide isomerase family A, member 4)


Additional Information