RGD Reference Report - alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. - Rat Genome Database

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alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells.

Authors: Elgoyhen, AB  Vetter, DE  Katz, E  Rothlin, CV  Heinemann, SF  Boulter, J 
Citation: Elgoyhen AB, etal., Proc Natl Acad Sci U S A 2001 Mar 13;98(6):3501-6.
RGD ID: 632443
Pubmed: PMID:11248107   (View Abstract at PubMed)
PMCID: PMC30682   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.051622798   (Journal Full-text)

We report the cloning and characterization of rat alpha10, a previously unidentified member of the nicotinic acetylcholine receptor (nAChR) subunit gene family. The protein encoded by the alpha10 nAChR subunit gene is most similar to the rat alpha9 nAChR, and both alpha9 and alpha10 subunit genes are transcribed in adult rat mechanosensory hair cells. Injection of Xenopus laevis oocytes with alpha10 cRNA alone or in pairwise combinations with either alpha2-alpha6 or beta2-beta4 subunit cRNAs yielded no detectable ACh-gated currents. However, coinjection of alpha9 and alpha10 cRNAs resulted in the appearance of an unusual nAChR subtype. Compared with homomeric alpha9 channels, the alpha9alpha10 nAChR subtype displays faster and more extensive agonist-mediated desensitization, a distinct current-voltage relationship, and a biphasic response to changes in extracellular Ca(2+) ions. The pharmacological profiles of homomeric alpha9 and heteromeric alpha9alpha10 nAChRs are essentially indistinguishable and closely resemble those reported for endogenous cholinergic eceptors found in vertebrate hair cells. Our data suggest that efferent modulation of hair cell function occurs, at least in part, through heteromeric nAChRs assembled from both alpha9 and alpha10 subunits.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cholinergic synapse is_active_inIDA 632443PMID:11248107SynGO 
cholinergic synapse is_active_inIMP 632443PMID:11248107SynGO 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Chrna10  (cholinergic receptor nicotinic alpha 10 subunit)

Objects referenced in this article
Gene Chrna9 cholinergic receptor nicotinic alpha 9 subunit Rattus norvegicus

Additional Information