RGD Reference Report - Molecular cloning of rat ATX1 homologue protein. - Rat Genome Database

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Molecular cloning of rat ATX1 homologue protein.

Authors: Hiromura, M  Sakurai, H 
Citation: Hiromura M and Sakurai H, Biochem Biophys Res Commun 1999 Nov 19;265(2):509-12.
RGD ID: 632007
Pubmed: PMID:10558899   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1999.1678   (Journal Full-text)

An ATX1 homologue of 503 bp length was cloned from a rat cDNA library, and the deduced protein from the cDNA was found to contain 68 amino acids with a predicted molecular mass of 7.2 kDa. The rat ATX1 homologue protein (Rah1p), which shows 35%, 38%, and 89% identities with Atx1p, CUC-1, and HAH1, respectively, conserves both the MTCXXC copper-binding site in the N terminus and the KTGK lysine-rich region in the C terminus. In Northern blot analysis, rah1 mRNA was found to be expressed at high levels in the liver, small intestine, and testis. Expression of rah1 cDNA complemented a null atx1 mutant strain in yeast. Thus, Rah1p was concluded to be a functional copper chaperone.

Objects referenced in this article
Gene Atox1 antioxidant 1 copper chaperone Rattus norvegicus

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