RGD Reference Report - A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system. - Rat Genome Database

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A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system.

Authors: Ryden, M  Imamura, T  Jornvall, H  Belluardo, N  Neveu, I  Trupp, M  Okadome, T  Ten Dijke, P  Ibanez, CF 
Citation: Ryden M, etal., J Biol Chem 1996 Nov 29;271(48):30603-9.
RGD ID: 631880
Pubmed: (View Article at PubMed) PMID:8940033

Receptor serine-threonine kinases (RSTK) mediate inhibitory as well as stimulatory signals for growth and differentiation by binding to members of the transforming growth factor-beta (TGF-beta) superfamily. Over 12 different RSTKs have been isolated so far, displaying wide expression in peripheral tissues and in the nervous system. Here we report the isolation and characterization of a novel type I RSTK termed activin receptor-like kinase-7 (ALK-7) that, unlike other members of this receptor family, is predominantly expressed in the adult central nervous system. The ALK-7 gene encodes a 55-kDa cell-surface protein that exhibits up to 78% amino acid sequence identity in the kinase domain to previously isolated type I receptors for TGF-beta and activin. In the extracellular domain, however, ALK-7 is more divergent, displaying comparable similarities with all members of the ALK subfamily. RNase protection and in situ hybridization studies demonstrated a highly specific mRNA distribution restricted to neurons in several regions of the adult rat central nervous system, including cerebellum, hippocampus, and nuclei of the brainstem. Receptor reconstitution and cross-linking experiments indicated that ALK-7 can form complexes with type II RSTKs for TGF-beta and activin in a ligand-dependent manner, although direct binding of ALK-7 to ligand in these complexes could not be demonstrated. The specific expression pattern of ALK-7, restricted to the postnatal central nervous system, indicates that this receptor may play an important role in the maturation and maintenance of several neuronal subpopulations.


Gene Ontology Annotations    

Biological Process

Cellular Component
cell surface  (IDA)

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Acvr1c  (activin A receptor type 1C)

Additional Information