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Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury.

Authors: Kholodilov, NG  Neystat, M  Oo, TF  Hutson, SM  Burke, RE 
Citation: Kholodilov NG, etal., Brain Res Mol Brain Res 2000 Feb 22;75(2):281-6.
Pubmed: (View Article at PubMed) PMID:10686349

We have previously shown that apoptotic cell death can be induced in substantia nigra (SN) by developmental striatal target lesion. In this model, only a portion of nigral neurons dies, so it provides a paradigm to examine not only the molecular basis of cell death, but also the cellular responses of adjacent neurons which survive. Using a differential display approach, we have found that cytosolic branched chain aminotransferase (BCATc) mRNA is upregulated in SN in this model. This upregulation is associated with an increased number of BCATc-positive neuronal profiles, demonstrated by immunostaining. BCATc-positive neurons show normal morphology and rarely contain apoptotic chromatin. We conclude that BCATc is upregulated in neurons, which are likely to survive, and plays a role in either maintenance of viability or restoration of normal function.

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RGD Object Information
RGD ID: 631308
Created: 2003-08-11
Species: All species
Last Modified: 2003-08-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.