RGD Reference Report - Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines. - Rat Genome Database

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Identification of quantitative trait loci influencing alcohol consumption in the high alcohol drinking and low alcohol drinking rat lines.

Authors: Foroud, T  Bice, P  Castelluccio, P  Bo, R  Miller, L  Ritchotte, A  Lumeng, L  Li, TK  Carr, LG 
Citation: Foroud T, etal., Behav Genet 2000 Mar;30(2):131-40.
RGD ID: 631230
Pubmed: PMID:10979603   (View Abstract at PubMed)

Selective breeding has been employed to develop high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rat lines from the heterogeneous N/Nih rat. Within-family selection and a rotational breeding design were used to discourage inbreeding (Li et al, 1993). To identify quantitative trait loci (QTLs) contributing to alcohol consumption, reciprocal HAD and LAD matings in conjunction with F1 intercrosses were used to create 459 F2 progeny. Using selective genotyping of 151 F2 progeny with extreme alcohol consumption scores and a novel least squares method developed by Haley et al (1994), five chromosomal regions (1, 5, 10, 12, and 16) were identified with lod scores greater than 2.0. Genotyping of the entire sample of 459 F2 progeny produced maximum lod scores of 3.5 on chromosome 5, 2.4 on chromosome 10, 4.7 on chromosome 12 and 2.9 on chromosome 16. The evidence of linkage to chromosome 1 diminished substantially to a maximum lod score of 0.5 when all F2 progeny were genotyped. This study is the first genome-wide study for QTLs underlying alcohol consumption that has employed noninbred lines. Further localization of these QTLs will likely provide insight and candidate genes for the study of human alcoholism.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Alc4Ratalcohol use disorder  IDA  RGD 
Alc6Ratalcohol use disorder  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Alc4Ratalcohol preference  QTM  RGD 
Alc5Ratalcohol preference  QTM  RGD 
Alc6Ratalcohol preference  QTM  RGD 

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Objects Annotated

QTLs
Alc4  (Alcohol consumption QTL 4)
Alc5  (Alcohol consumption QTL 5)
Alc6  (Alcohol consumption QTL 6)

Strains
Iusm:HAD1  (high-alcohol-drinking)
Iusm:LAD1  (low-alcohol-drinking)

Objects referenced in this article
QTL Alc7 Alcohol consumption QTL 7 Rattus norvegicus
Strain Iusm:HAD2 high-alcohol-drinking Rattus norvegicus
Strain Iusm:LAD2 low-alcohol-drinking Rattus norvegicus

Additional Information