RGD Reference Report - Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats. - Rat Genome Database

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Segregation of autoimmune type 1 diabetes in a cross between diabetic BB and brown Norway rats.

Authors: Jackerott, M  Hornum, L  Andreasen, BE  Markholst, H 
Citation: Jackerott M, etal., J Autoimmun 1997 Feb;10(1):35-41.
RGD ID: 631165
Pubmed: PMID:9080298   (View Abstract at PubMed)
DOI: DOI:10.1006/jaut.1996.0105   (Journal Full-text)

Diabetes-prone DP-BB rats spontaneously develop insulin-dependent diabetes mellitus resembling type 1 diabetes mellitus in man. Expression of T cell lymphopenia and presence of at least one class II major histocompatibility complex (MHC) RT1u haplotype are required for development of diabetes. Diabetes segregation was studied in lymphopenic backcross (BC) offspring from a cross between male DP-BB/HRI and female BN/Mol rats. Diabetes occurred in 75% of BC rats with genotype RT1u/u and in 18% of those being RT1n/u in genotype. The latter developed diabetes significantly later than MHC homozygotes and parental DP-BBs. Our data further point to the existence of additional genes of minor importance for development of IDDM. One of these seemed to be positioned on the X chromosome. The recently published linkage to chromosome 18 could not be confirmed however. Finally, the BN-derived non-albino allele of the C gene was associated with higher diabetes incidence. This points to the existence of minor susceptibility genes in other strains of rats.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BBDP/HriRattype 1 diabetes mellitus susceptibilityIAGP  RGD 
Iddm7Rattype 1 diabetes mellitus  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Iddm7Ratincreased circulating glucose level  IAGP  RGD 
Objects Annotated

QTLs
Iddm7  (Insulin dependent diabetes mellitus QTL 7)

Strains
BBDP/Hri  (NA)
BN/Mol  (NA)

Objects referenced in this article
Strain BB/OK BioBreeding rat Rattus norvegicus

Additional Information