RGD Reference Report - New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis. - Rat Genome Database

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New loci regulating rat myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis.

Authors: Becanovic, K  Wallstrom, E  Kornek, B  Glaser, A  Broman, KW  Dahlman, I  Olofsson, P  Holmdahl, R  Luthman, H  Lassmann, H  Olsson, T 
Citation: Becanovic K, etal., J Immunol 2003 Jan 15;170(2):1062-9.
RGD ID: 629629
Pubmed: PMID:12517974   (View Abstract at PubMed)

Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in rats that closely mimics many clinical and histopathological aspects of multiple sclerosis. Non-MHC quantitative trait loci regulating myelin oligodendrocyte glycoprotein-induced EAE have previously been identified in the EAE-permissive strain, DA, on rat chromosomes 4, 10, 15, and 18. To find any additional gene loci in another well-known EAE-permissive strain and thereby to assess any genetic heterogeneity in the regulation of the disease, we have performed a genome-wide linkage analysis in a reciprocal (LEW.1AV1 x PVG.1AV1) male/female F(2) population (n = 185). We examined reciprocal crosses, but no parent-of-origin effect was detected. The parental rat strains share the RT1(av1) MHC haplotype; thus, non-MHC genes control differences in EAE susceptibility. We identified Eae16 on chromosome 8 and Eae17 on chromosome 13, significantly linked to EAE phenotypes. Two loci, on chromosomes 1 and 17, respectively showed suggestive linkage to clinical and histopathological EAE phenotypes. Eae16 and Eae17 differ from those found in previously studied strain combinations, thus demonstrating genetic heterogeneity of EAE. Furthermore, we detected a locus-specific parent-of-origin effect with suggestive linkage in Eae17. Further genetic and functional dissection of these loci may disclose critical disease-regulating molecular mechanisms.



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Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Eae16Ratabnormal voluntary movement  IDA  RGD 
Eae17Ratabnormal voluntary movement  IDA  RGD 
Eae16RatCNS inflammation  IDA  RGD 
Eae17RatCNS inflammation  IDA  RGD 
Objects Annotated

QTLs
Eae16  (Experimental allergic encephalomyelitis QTL 16)
Eae17  (Experimental allergic encephalomyelitis QTL 17)
Eae32  (Experimental allergic encephalomyelitis QTL 32)
Eae33  (Experimental allergic encephalomyelitis QTL 33)

Strains
DA.PVG.1AV1-(D17Rat8-D17Rat37)/Kini  (NA)
Kini:DA,PVG-G10  (NA)
LEW.1AV1  (NA)
PVG.1AV1  (Piebald-Virol-Glaxo)


Additional Information