RGD Reference Report - Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Interaction between blood pressure quantitative trait loci in rats in which trait variation at chromosome 1 is conditional upon a specific allele at chromosome 10.

Authors: Monti, J  Plehm, R  Schulz, H  Ganten, D  Kreutz, R  Hubner, N 
Citation: Monti J, etal., Hum Mol Genet 2003 Feb 15;12(4):435-9.
RGD ID: 629620
Pubmed: PMID:12566390   (View Abstract at PubMed)

We have used inbred and congenic rat strains in F(2) segregation studies to discover epistasis in a polygenic model of hypertension. Previously, we have found evidence that the presence of a blood pressure quantitative trait locus (QTL) on chromosome 1 is conditional upon the allele status of chromosome 10. To prove the existence of an epistatic interaction we have analyzed congenic strains for chromosome 1 and 10 carrying high blood pressure QTL alleles from the spontaneously hypertensive rat on a normotensive background of the Wistar-Kyoto (WKY) rat. Additionally, a double congenic strain was developed with both chromosome 1 and 10 high blood pressure QTL alleles on the WKY background. Analysis of variance for blood pressure phenotypes as determined by radiotelemetry showed a significant effect for chromosome 10 but not chromosome 1 QTL alleles and demonstrated a significant interaction between the two loci (P<0.05). The interaction accounted for 5 mmHg of blood pressure. Thus, the identification of epistasis is critical to the understanding of the quantitative nature of blood pressure genetics.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp106Rathypertension  IDA  RGD 
Bp107Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
WKY/BbbRatdecreased systemic arterial diastolic blood pressure susceptibilityIAGPcontrolled sodium content drinking watercompared to WKY.SHRSP-D1Rat200-D1Rat216Shbg-Atp1b2/Bbb and MMO:0000015RGD 
WKY/BbbRatdecreased systemic arterial systolic blood pressure susceptibilityIAGPcontrolled sodium content drinking watercompared to WKY.SHRSP-D1Rat200-D1Rat216Shbg-Atp1b2/Bbb and MMO:0000015RGD 
Bp106Ratincreased systemic arterial blood pressure  IAGP  RGD 
Bp107Ratincreased systemic arterial blood pressure  IAGP  RGD 
WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/BbbRatincreased systemic arterial blood pressure susceptibilityIAGPcontrolled sodium content drinking watercompared to WKY/Bbb and MMO:0000015RGD 
WKY.SHRSP-(D1Rat200-D1Rat216)/BbbRatincreased systemic arterial blood pressure susceptibilityIAGPcontrolled sodium content drinking watercompared to WKY/Bbb and MMO:0000015RGD 
WKY.SHRSP-(Asgr1-Vamp2)/BbbRatincreased systemic arterial blood pressure susceptibilityIAGPcontrolled sodium content drinking watercompared to WKY/Bbb and MMO:0000015RGD 
WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/BbbRatincreased systemic arterial diastolic blood pressure susceptibilityIAGPcontrolled sodium content drinking watercompared to WKY/Bbb and MMO:0000015RGD 
WKY.SHRSP-(D1Rat200-D1Rat216)(Shbg-Atp1b2)/BbbRatincreased systemic arterial systolic blood pressure susceptibilityIAGPcontrolled sodium content drinking watercompared to WKY/Bbb and MMO:0000015RGD 

Related Phenotype Data for this Reference

Phenominer Options:  View all phenotype data for this reference  |  Download all phenotype data for this reference

Select a value below to view phenotype data for a specific strain, measurment, or condition.

Objects Annotated

QTLs
Bp106  (Blood pressure QTL 106)
Bp107  (Blood pressure QTL 107)

Objects referenced in this article
Strain WKY.SHRSP-(Shbg-Atp1b2)/Bbb null Rattus norvegicus

Additional Information