RGD Reference Report - Defining the blood pressure QTL on Chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1. - Rat Genome Database

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Defining the blood pressure QTL on Chromosome 7 in Dahl rats by a 177-kb congenic segment containing Cyp11b1.

Authors: Garrett, MR  Rapp, JP 
Citation: Garrett MR and Rapp JP, Mamm Genome 2003 Apr;14(4):268-73.
RGD ID: 629613
Pubmed: PMID:12682779   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-002-2245-9   (Journal Full-text)

Previously we reported that there is a blood pressure quantitative trait locus (QTL) on rat Chromosome (Chr) 7 seen when comparing Dahl salt-sensitive (S) rats and Dahl salt-resistant (R) rats. Evidence was also presented that this QTL was due to genetic variants in the adrenal steroidogenic enzyme 11beta-hydroxylase ( Cyp11b1). A series of congenic strains supported this contention. In the present work we have constructed a final congenic substrain that retains a blood pressure effect and that has an introgressed congenic segment which includes Cyp11b1 and is < 177 kb in size. None of the other genes in the congenic region (eight known genes) have known biological functions for influencing blood pressure. We believe that we have reached the limit of resolution for congenic analysis of a QTL in a rodent animal model, and we conclude that Cyp11b1 causes the observed QTL on rat Chr 7 in Dahl rats.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased heart weight  IMP 629613compared to SS/JrRGD 
decreased heart weight  IAGP 629613; 629613; 629613compared to SS/JrRGD 
decreased systemic arterial systolic blood pressure  IAGP 629613as compared to SS/Jr on 2% NaCl dietRGD 
decreased systemic arterial systolic blood pressure MODEL: inducedIMP 629613compared to SS/Jr on 2% Nacl dietRGD 
decreased systemic arterial systolic blood pressure MODEL: inducedIAGP 629613as compared to SS/Jr on 4% Nacl dietRGD 
decreased systemic arterial systolic blood pressure MODEL: inducedIAGP 629613; 629613as compared to SS/Jr on 2% Nacl dietRGD 
salt-sensitive hypertension  IAGP 629613; 629613compared to SS/Jr and congenicsRGD 
Objects referenced in this article
QTL Bp169 Blood pressure QTL 169 Rattus norvegicus

Additional Information