RGD Reference Report - Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2. - Rat Genome Database

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Congenic strains for the blood pressure quantitative trait locus on rat chromosome 2.

Authors: Deng, AY  Dene, H  Rapp, JP 
Citation: Deng AY, etal., Hypertension 1997 Aug;30(2 Pt 1):199-202.
RGD ID: 629612
Pubmed: PMID:9260980   (View Abstract at PubMed)

A quantitative trait locus (QTL) for blood pressure was previously detected by linkage analysis in a region of rat chromosome 2 using segregating populations derived from crosses of the Dahl salt-sensitive (Dahl S) rat with rats of the Wistar-Kyoto (WKY) strain or Milan normotensive strain (MNS). Two congenic strains, S.WKY-D2N35/Nep and S.MNS-Adh/D2Mit5, have been constructed by replacing a region of chromosome 2 of the Dahl S rat with the homologous region (ie, low blood pressure QTL allele) of either the WKY or MNS rat, respectively. Systolic pressures of congenic strains S.WKY-D2N35/Nep and S.MNS-Adh/D2Mit5 fed a 2% NaCl diet for 24 days were 44+/-4.6 and 29+/-4.5 mm Hg lower, respectively, than that of the comparably treated Dahl S rats. The differences between congenic and Dahl S rats in blood pressure were highly significant (P<.001) and were corroborated by significantly (P<.001) lower ratio of heart weight to body weight in the congenic strains compared with Dahl S rats. The data from two congenic strains combined unequivocally establish the existence of a blood pressure QTL on rat chromosome 2.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 629612 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased systemic arterial systolic blood pressure  IAGP 629612 RGD 

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Objects Annotated

QTLs
Bp239  (Blood pressure QTL 239)

Objects referenced in this article
Strain SS.WKY-(D2N35-Mme)/Mco null Rattus norvegicus

Additional Information