RGD Reference Report - The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth. - Rat Genome Database

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The basic region and leucine zipper transcription factor MafK is a new nerve growth factor-responsive immediate early gene that regulates neurite outgrowth.

Authors: Torocsik, B  Angelastro, JM  Greene, LA 
Citation: Torocsik B, etal., J Neurosci 2002 Oct 15;22(20):8971-80.
RGD ID: 628386
Pubmed: PMID:12388604   (View Abstract at PubMed)
PMCID: PMC6757672   (View Article at PubMed Central)

We used serial analysis of gene expression to identify new NGF-responsive immediate early genes (IEGs) with potential roles in neuronal differentiation. Among those identified was MafK, a small Maf family basic region and leucine zipper transcriptional repressor and coactivator expressed in immature neurons. NGF treatment elevates the levels of both MafK transcripts and protein. In contrast, there is no effect on expression of the closely related MafG. Unlike many other NGF-responsive IEGs, MafK regulation shows selectivity and is unresponsive to epidermal growth factor, depolarization, or cAMP derivatives. Inhibitor studies indicate that NGF-promoted MafK regulation is mediated by an atypical isoform of PKC but not by mitogen-activated kinase kinase, phospholipase Cgamma, or phosphoinositide 3'-kinase. Interference with MafK expression or activity by small interfering RNA and dominant negative strategies, respectively, suppresses NGF-promoted outgrowth and maintenance of neurites by PC12 cells and neurite outgrowth by immature telencephalic neurons. Our findings support a role for MafK as a novel regulator of neuronal differentiation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nervous system development  IDA 628386 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mafk  (MAF bZIP transcription factor K)

Objects referenced in this article
Gene Mafk v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Mus musculus

Additional Information