RGD Reference Report - Effect of annexin I on insulin secretion through surface binding sites in rat pancreatic islets. - Rat Genome Database

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Effect of annexin I on insulin secretion through surface binding sites in rat pancreatic islets.

Authors: Hong, SH  Won, JH  Yoo, SA  Auh, CK  Park, YM 
Citation: Hong SH, etal., FEBS Lett 2002 Dec 4;532(1-2):17-20.
RGD ID: 628365
Pubmed: PMID:12459455   (View Abstract at PubMed)

This study investigates the effect of extracellular annexin I (Anx I) on regulating insulin secretion in isolated rat pancreatic islets. Results show that Anx I stimulates insulin release in pancreatic islets regardless of the presence or absence of extracellular Ca(2+). In particular, confocal microscopy shows that Anx I binds to the surface of islet cells in the absence of extracellular Ca(2+). However, insulin secretion through Anx I significantly decreases in trypsin-treated islets. Likewise, there is minimal binding of Anx I to the surface of trypsin-treated islets. Anti-Anx I polyclonal antibody also inhibits the stimulating effect of Anx I on insulin secretion. These results indicate that Anx I is capable of binding to the cell surface receptor, in order to regulate the stimulation of insulin release in rat pancreatic islets.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cell surface receptor signaling pathway  IDA 628365 RGD 
insulin secretion  IDA 628365 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
calcium-dependent phospholipid binding  TAS 628365 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Anxa1  (annexin A1)


Additional Information