RGD Reference Report - Ghrelin is a growth-hormone-releasing acylated peptide from stomach. - Rat Genome Database

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Ghrelin is a growth-hormone-releasing acylated peptide from stomach.

Authors: Kojima, M  Hosoda, H  Date, Y  Nakazato, M  Matsuo, H  Kangawa, K 
Citation: Kojima M, etal., Nature 1999 Dec 9;402(6762):656-60.
RGD ID: 625505
Pubmed: PMID:10604470   (View Abstract at PubMed)
DOI: DOI:10.1038/45230   (Journal Full-text)

Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through GHS-R, a G-protein-coupled receptor for which the ligand is unknown. Recent cloning of GHS-R strongly suggests that an endogenous ligand for the receptor does exist and that there is a mechanism for regulating GH release that is distinct from its regulation by hypothalamic growth-hormone-releasing hormone (GHRH). We now report the purification and identification in rat stomach of an endogenous ligand specific for GHS-R. The purified ligand is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated. The acylated peptide specifically releases GH both in vivo and in vitro, and O-n-octanoylation at serine 3 is essential for the activity. We designate the GH-releasing peptide 'ghrelin' (ghre is the Proto-Indo-European root of the word 'grow'). Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
G protein-coupled receptor signaling pathway involved_inIDA 625505PMID:10604470UniProt 
positive regulation of growth hormone secretion involved_inIDA 625505PMID:10604470CACAO 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
extracellular space located_inICGO:0016608625505PMID:10604470UniProt 

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Ghrl  (ghrelin and obestatin prepropeptide)
Ghsr  (growth hormone secretagogue receptor)


Additional Information