RGD Reference Report - Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline. - Rat Genome Database

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Locus on chromosome 18 cosegregates with diabetes in the BB/OK rat subline.

Authors: Kloting, I  Vogt, L  Serikawa, T 
Citation: Kloting I, etal., Diabete Metab 1995 Dec;21(5):338-44.
RGD ID: 625443
Pubmed: PMID:8586150   (View Abstract at PubMed)

The spontaneously diabetic BB rat is a well-established animal model of human insulin-dependent diabetes mellitus. Besides the lymphopenia gene (Iddm 1) and the MHC class-II genes of the RT1u haplotype (Iddm 2), at least one other non-MHC gene (Iddm 3) is considered essential for diabetes development. To investigate the participation of this third gene in the development of diabetes in our BB/OK rat subline, we analysed 119 [(BB/OK x DA)F1 x BB/OK] first backcross hybrids phenotypically and genotypically. Genotyping with 5 classical and 28 polymorphic microsatellite markers indicated that the third gene is located on chromosome 18, about 22 +/- 7 cM distal from the Olf locus (Iod score = 2.33). Significantly more diabetics than Iddm 1 and Iddm 2 homozygous nondiabetic subjects were homozygous for this locus. Interacting genes located on chromosomes X and/or 1 seem to be involved.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Iddm5Rattype 1 diabetes mellitus  QTM  RGD 
Iddm6Rattype 1 diabetes mellitus  QTM  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Iddm5Ratincreased circulating glucose level  IDA  RGD 
Iddm6Ratincreased circulating glucose level  IDA  RGD 
Objects Annotated

Iddm4  (Insulin dependent diabetes mellitus QTL 4)
Iddm5  (Insulin dependent diabetes mellitus QTL 5)
Iddm6  (Insulin dependent diabetes mellitus QTL 6)

BB/OK  (BioBreeding rat)
DA  (DA)

Additional Information