RGD Reference Report - The influence of sex and estrous cycle on QTL for emotionality and ethanol consumption. - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

The influence of sex and estrous cycle on QTL for emotionality and ethanol consumption.

Authors: Izidio, GS  Oliveira, LC  Oliveira, LF  Pereira, E  Wehrmeister, TD  Ramos, A 
Citation: Izidio GS, etal., Mamm Genome. 2011 Jun;22(5-6):329-40. Epub 2011 Apr 24.
RGD ID: 6218999
Pubmed: PMID:21516450   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-011-9327-5   (Journal Full-text)

The inbred rat strains Lewis (LEW) and Spontaneously Hypertensive Rats (SHR) differ with respect to several emotionality- and ethanol intake-related behaviors, one of which (inner locomotion in the open field; OF) is strongly influenced by a locus (Anxrr16) on chromosome (Chr) 4. We aimed to further investigate the influence of Chr 4 on these behaviors and to evaluate the role of the estrous cycle in QTL expression. LEW females and SHR males were intercrossed to produce F1 and F2 rats (96-97/sex), which were then tested in the OF, light-dark box (LDB), forced swimming test (FST), and an ethanol consumption procedure (ECP). In addition, another group of 96 F2 females were tested in the OF and LDB according to their estrous cycle phase. All animals were genotyped for microsatellite markers located on Chr 4 and two QTL analyses were performed. A factor analysis of the F2 population produced five factors reflecting different behavioral dimensions. QTL analysis revealed five significant loci in males, some of which with pleiotropic effects on behaviors measured in the OF, LDB, and ECP. The second QTL analysis revealed two significant loci in females in diestrous-proestrous and one in females in estrous-metestrous that influence behaviors in the OF and LDB. Results revealed that Anxrr16 and four other new QTL influence emotionality- and ethanol-related behaviors in male rats, whereas Anxrr16 attained suggestive levels only in females in diestrous-proestrous, which raises the need for taking into account factors related to the sex and estrous cycle in behavioral QTL analysis.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Alc23  (Alcohol consumption QTL 23)
Anxrr29  (Anxiety related response QTL 29)
Anxrr30  (Anxiety related response QTL 30)
Anxrr31  (Anxiety related response QTL 31)
Anxrr32  (Anxiety related response QTL 32)
Anxrr33  (Anxiety related response QTL 33)
Anxrr34  (Anxiety related response QTL 34)
Anxrr35  (Anxiety related response QTL 35)
Anxrr36  (Anxiety related response QTL 36)
Anxrr37  (Anxiety related response QTL 37)
Anxrr38  (Anxiety related response QTL 38)
Anxrr39  (Anxiety related response QTL 39)
Anxrr40  (Anxiety related response QTL 40)
Anxrr41  (Anxiety related response QTL 41)
Anxrr42  (Anxiety related response QTL 42)
Anxrr43  (Anxiety related response QTL 43)
Anxrr44  (Anxiety related response QTL 44)
Anxrr45  (Anxiety related response QTL 45)
Anxrr46  (Anxiety related response QTL 46)
Anxrr47  (Anxiety related response QTL 47)
Anxrr48  (Anxiety related response QTL 48)
Anxrr49  (Anxiety related response QTL 49)
Anxrr50  (Anxiety related response QTL 50)
Anxrr51  (Anxiety related response QTL 51)
Anxrr52  (Anxiety related response QTL 52)
Anxrr53  (Anxiety related response QTL 53)

Strains
LEW/HsdUnibAnra  (NA)
SHR/NCrlAnra  (NA)

Objects referenced in this article
QTL Anxrr16 Anxiety related response QTL 16 Rattus norvegicus

Additional Information