RGD Reference Report - Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF. - Rat Genome Database

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Genetic evidence for obesity loci involved in the regulation of body fat distribution in obese type 2 diabetes rat, OLETF.

Authors: Ogino, T  Wei, S  Wei, K  Moralejo, DH  Kose, H  Mizuno, A  Shima, K  Sasaki, Y  Yamada, T  Matsumoto, K 
Citation: Ogino T, etal., Genomics 2000 Nov 15;70(1):19-25.
RGD ID: 619690
Pubmed: PMID:11087657   (View Abstract at PubMed)
DOI: DOI:10.1006/geno.2000.6349   (Journal Full-text)

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes in human. Obesity is essential for the onset of type 2 diabetes in this rat. Our present investigation was designed to identify quantitative trait loci (QTLs) contributing to obesity by performing a whole-genome search using 214 F(2) intercross progeny between OLETF and F344 rats. We have identified six QTLs responsible for adiposity indices of fat pads on rat chromosomes 2 (Obs1 for mesenteric fat), 4 (Obs2 for retroperitoneal fat), 8 (Obs3 for mesenteric fat), 9 (Obs4 for retroperitoneal fat), and 14 (Obs5 and Obs6 for retroperitoneal fat), demonstrating that the adiposity indices of individual fat pads were under the control of different genes. As expected, the OLETF allele corresponds to increased adiposity indices for all QTLs, except for Obs3, in which the F344 allele leads to an increase in the index.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
obesity  IDA 619690; 619690; 619690; 619690; 619690; 619690 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
abnormal abdominal fat pad morphology  QTM 619690; 619690 RGD 
abnormal retroperitoneal fat pad morphology  QTM 619690; 619690; 619690; 619690 RGD 
hyperglycemia  IAGP 619690compared to F344/DuCrlCrljRGD 
increased fasting circulating glucose level  IAGP 619690compared to F344/DuCrlCrljRGD 

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Objects Annotated

QTLs
Bw1  (Body weight QTL1)
Bw2  (Body weight QTL2)
Bw3  (Body weight QTL3)
Bw4  (Body weight QTL4)
Bw5  (Body weight QTL5)
Bw60  (Body weight QTL60)

Strains
F344/NRrrc  (NA)
OLETF  (Otsuka Long-Evans Tokushima fatty)
OLETF/Got  (Otsuka Long Evans Tokushima)


Additional Information