RGD Reference Report - Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains.

Authors: Kloting, I  Van den Brandt, J  Kuttler, B 
Citation: Kloting I, etal., Biochem Biophys Res Commun 2001 May 4;283(2):399-405.
RGD ID: 619685
Pubmed: (View Article at PubMed) PMID:11327715
DOI: Full-text: DOI:10.1006/bbrc.2001.4798

Diabetes in BB rats share many common features with human type 1 diabetes. One of them is the complex and polygenic nature of disease. Analysis of cross hybrids of diabetic BB/OK rats and rats of different diabetes-resistant strains has demonstrated that beside the MHC genes, Iddm1 and the lymphopenia, Iddm2, additional non-MHC genes are involved in diabetes development. To study the importance of the non-MHC genes, Iddm4 and Iddm3, two congenic BB.SHR rat strains were generated by recombining a segment of the SHR chromosome 6 (Iddm4; termed BB.6S; 15cM) or chromosome 18 (Iddm3; termed BB.18S; 24cM) into the BB/OK background by serial backcrossing and marker-aided selection. The characterization of both congenic strains demonstrates a drastic reduction of diabetes frequency in comparison to the BB/OK strain (86% vs 14% and 34%). It is supposed that diabetes protective genes of SHR must be located on both chromosomal segments and that these suppress the action of the essential and most important genes of diabetes development in the BB/OK rat, Iddm1, and Iddm2.



Disease Annotations    


Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table  |  Show All Strains Clinical Measurement

Strains with Phenominer Data Strains with phenominer data
BB.SHR-(D6Rat184-D6Rat3)/K BB.SHR-(Gnal-D18Mit9)/K

Objects Annotated

QTLs
Iddm15  (Insulin dependent diabetes mellitus QTL 15)
Iddm18  (Insulin dependent diabetes mellitus QTL 18)

Strains
BB.SHR-(Gnal-D18Mit9)/K  (NA)
BB.SHR-(D6Rat184-D6Rat3)/K  (NA)
BB/OK  (BioBreeding rat)

Objects referenced in this article
QTL Iddm8 Insulin dependent diabetes mellitus QTL 8 Rattus norvegicus

Additional Information