RGD Reference Report - Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains. - Rat Genome Database

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Genes of SHR rats protect spontaneously diabetic BB/OK rats from diabetes: lessons from congenic BB.SHR rat strains.

Authors: Kloting, I  Van den Brandt, J  Kuttler, B 
Citation: Kloting I, etal., Biochem Biophys Res Commun 2001 May 4;283(2):399-405.
RGD ID: 619685
Pubmed: PMID:11327715   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.4798   (Journal Full-text)

Diabetes in BB rats share many common features with human type 1 diabetes. One of them is the complex and polygenic nature of disease. Analysis of cross hybrids of diabetic BB/OK rats and rats of different diabetes-resistant strains has demonstrated that beside the MHC genes, Iddm1 and the lymphopenia, Iddm2, additional non-MHC genes are involved in diabetes development. To study the importance of the non-MHC genes, Iddm4 and Iddm3, two congenic BB.SHR rat strains were generated by recombining a segment of the SHR chromosome 6 (Iddm4; termed BB.6S; 15cM) or chromosome 18 (Iddm3; termed BB.18S; 24cM) into the BB/OK background by serial backcrossing and marker-aided selection. The characterization of both congenic strains demonstrates a drastic reduction of diabetes frequency in comparison to the BB/OK strain (86% vs 14% and 34%). It is supposed that diabetes protective genes of SHR must be located on both chromosomal segments and that these suppress the action of the essential and most important genes of diabetes development in the BB/OK rat, Iddm1, and Iddm2.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Iddm15Ratdiabetes mellitus  IAGP  RGD 
BB.SHR-(Gnal-D18Mit9)/KRattype 1 diabetes mellitus  IAGP  RGD 
BB.SHR-(D6Rat184-D6Rat3)/KRattype 1 diabetes mellitus  IAGP  RGD 
BB/OKRattype 1 diabetes mellitus penetranceIAGP compared to SHR/Mol more ...RGD 
Iddm18Rattype 1 diabetes mellitus  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BB.SHR-(D6Rat184-D6Rat3)/KRatdecreased activated T cell number  IAGP compared to BB/OKRGD 
Iddm15Ratdecreased circulating glucose level  IAGP  RGD 
BB.SHR-(Gnal-D18Mit9)/KRatdecreased leukocyte cell number  IAGP compared to BB/OKRGD 
BB.SHR-(Gnal-D18Mit9)/KRatdecreased susceptibility to autoimmune diabetes  IAGP compared to BB/OKRGD 
BB.SHR-(D6Rat184-D6Rat3)/KRatdecreased susceptibility to autoimmune diabetes  IAGP compared to BB/OKRGD 
Iddm15Ratdecreased urine glucose level  IAGP  RGD 
BB.SHR-(Gnal-D18Mit9)/KRatincreased body weight  IAGP compared to BB/OK and sexual dimorphismRGD 
BB.SHR-(D6Rat184-D6Rat3)/KRatincreased body weight  IAGP compared to BB/OK and sexual dimorphismRGD 
Iddm18Ratincreased body weight  IAGP  RGD 
BB.SHR-(Gnal-D18Mit9)/KRatincreased circulating cholesterol level  IAGP compared to BB/OK and sexual dimorphismRGD 
BB.SHR-(D6Rat184-D6Rat3)/KRatincreased circulating cholesterol level  IAGP compared to BB/OKRGD 
Iddm18Ratincreased circulating cholesterol level  IAGP  RGD 
BB.SHR-(Gnal-D18Mit9)/KRatincreased circulating glucose level  IAGP  RGD 
BB.SHR-(Gnal-D18Mit9)/KRatincreased circulating triglyceride level  IAGP compared to BB/OK and sexual dimorphismRGD 
BB.SHR-(D6Rat184-D6Rat3)/KRatincreased circulating triglyceride level  IAGP compared to BB/OK and sexual dimorphismRGD 
Iddm18Ratincreased circulating triglyceride level  IAGP  RGD 
BB.SHR-(D6Rat184-D6Rat3)/KRatincreased T-helper 2 cell number  IAGP compared to BB/OKRGD 

Related Phenotype Data for this Reference

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Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:
Objects Annotated

QTLs
Iddm15  (Insulin dependent diabetes mellitus QTL 15)
Iddm18  (Insulin dependent diabetes mellitus QTL 18)

Strains
BB.SHR-(Gnal-D18Mit9)/K  (NA)
BB.SHR-(D6Rat184-D6Rat3)/K  (NA)
BB/OK  (BioBreeding rat)

Objects referenced in this article
QTL Iddm8 Insulin dependent diabetes mellitus QTL 8 Rattus norvegicus

Additional Information