Quantitative trait locus analysis for chronic pancreatitis and diabetes mellitus in the WBN/Kob rat.

Authors: Tsuji, A  Nishikawa, T  Mori, M  Suda, K  Nishimori, I  Nishimura, M 
Citation: Tsuji A, etal., Genomics 2001 Jun 15;74(3):365-9.
Pubmed: (View Article at PubMed) PMID:11414764
DOI: Full-text: DOI:10.1006/geno.2001.6557

A causative gene mutation is still undefined in approximately half of patients with hereditary pancreatitis, and no genetic factor has been identified in most patients with sporadic chronic pancreatitis. To identify a pancreatitis-associated gene, we performed a quantitative trait locus (QTL) analysis for the traits of chronic pancreatitis and diabetes mellitus in WBN/Kob rats. We identified two highly significant QTLs for chronic pancreatitis and/or hyperinsulinemia on chromosomes 7 and X. These QTLs were located on completely different chromosomal regions from those of causative genes that have been reported for human chronic pancreatitis: PRSS1, CFTR, and SPINK1. For these QTLs, prevalences of the WBN/Kob allele significantly increased in the rats with chronic pancreatitis. These findings indicate that chronic pancreatitis in WBN/Kob rats is controlled by multiple genes, and a genetic analysis in WBN/Kob rats might be useful for gene targeting for human chronic pancreatitis.


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RGD ID: 619682
Created: 2002-08-05
Species: All species
Last Modified: 2002-08-05
Status: ACTIVE