Effects of Dmo1 on obesity, dyslipidaemia and hyperglycaemia in the Otsuka Long Evans Tokushima Fatty strain.

Authors: Okuno, S  Watanabe, TK  Ono, T  Oga, K  Mizoguchi-Miyakita, A  Yamasaki, Y  Goto, Y  Shinomiya, H  Momota, H  Miyao, H  Hayashi, I  Asai, T  Suzuki, M  Harada, Y  Hishigaki, H  Wakitani, S  Takagi, T  Nakamura, Y  Tanigami, A 
Citation: Okuno S, etal., Genet Res 2001 Apr;77(2):183-90.
Pubmed: (View Article at PubMed) PMID:11355573

Whole-genome scans have identified Dmo1 as a major quantitative trait locus (QTL) for obesity and dyslipidaemia in the Otsuka Long Evans Tokushima Fatty (OLETF) rat. We have produced congenic rats for the Dmo1 locus, using marker-assisted speed congenic protocols, enforced by selective removal of other QTL regions (QTL-marker-assisted counterselection), to efficiently transfer chromosomal segments from non-diabetic Fischer 344 (F344) rats into the OLETF background. In the third generation of congenic animals, we observed a substantial therapeutic effect of the Dmo1 locus on lipid metabolism, obesity control and plasma glucose homeostasis. We conclude that single-allele correction of an impaired genetic pathway can generate a substantial therapeutic effect, despite the complex polygenic nature of type II diabetic syndromes.


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Created: 2002-08-05
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