RGD Reference Report - Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat. - Rat Genome Database

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Identification of possible quantitative trait loci responsible for hyperglycaemia after 70% pancreatectomy using a spontaneously diabetogenic rat.

Authors: Ogino, T  Moralejo, DH  Zhu, M  Toide, K  Wei, S  Wei, K  Yamada, T  Mizuno, A  Matsumoto, K  Shima, K 
Citation: Ogino T, etal., Genet Res 1999 Feb;73(1):29-36.
RGD ID: 619676
Pubmed: PMID:10218444   (View Abstract at PubMed)

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type non-insulin-dependent diabetes mellitus (NIDDM) in humans. The OLETF rat exhibits sustained hyperglycaemia after partial pancreatectomy, while the normal control rat does not. This difference is thought to be genetically determined and to be caused by impairment of beta-cell regrowth, a possible event involved in the pathogenesis of NIDDM. Our investigation was designed to identify quantitative trait loci (QTL) responsible for post-pancreatectomy hyperglycaemia by performing a genome-wide scan in an F2 intercross obtained by mating the OLETF and Fischer-344 (F344) rats. We have identified three possible QTL on rat chromosomes (Chrs) 3, 14 and 19 that account for a total of approximately 75% of the genetic variance in the F2. For the QTL on Chr 14, the OLETF allele corresponds with increased glucose levels, as expected. Surprisingly, for the QTL on Chr 19, the F344 allele corresponds with increased glucose levels. The Chr 3 QTL exhibits heterosis, heterozygotes showing significantly higher glucose levels than OLETF or F344 homozygotes. We also found evidence for interaction (epistasis) between the QTL on Chrs 14 and 19.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Niddm37Rathyperglycemia  QTM  RGD 
Niddm38Rathyperglycemia  QTM  RGD 
Niddm39Rathyperglycemia  QTM  RGD 
Niddm37Rattype 2 diabetes mellitus  QTM  RGD 
Niddm38Rattype 2 diabetes mellitus  QTM  RGD 
Niddm39Rattype 2 diabetes mellitus  QTM  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Niddm37Ratincreased circulating glucose level  IDA  RGD 
Niddm38Ratincreased circulating glucose level  IDA  RGD 
Niddm39Ratincreased circulating glucose level  IDA  RGD 

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Objects Annotated

QTLs
Niddm37  (Non-insulin dependent diabetes mellitus QTL 37)
Niddm38  (Non-insulin dependent diabetes mellitus QTL 38)
Niddm39  (Non-insulin dependent diabetes mellitus QTL 39)

Strains
F344/NRrrc  (NA)
OLETF  (Otsuka Long-Evans Tokushima fatty)


Additional Information