RGD Reference Report - Mining the quantitative trait loci associated with oral glucose tolerance in the OLETF rat. - Rat Genome Database

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Mining the quantitative trait loci associated with oral glucose tolerance in the OLETF rat.

Authors: Nakaya, A  Hishigaki, H  Morishita, S 
Citation: Nakaya A, etal., Pac Symp Biocomput 2000;:367-79.
RGD ID: 619671
Pubmed: PMID:10902185   (View Abstract at PubMed)

Although the synergetic effects of multiple marker loci regarding quantitative traits such as blood glucose level have attracted interest, previous conclusions have been based on assumptions that each marker locus behaves independently of the other, leading to approximation. To cope with this problem, this paper focuses on the effects of multiple genetic factors and tries to find significant marker combinations by using conjunctive rules regarding genotypes at multiple marker loci. Application of the proposed method on the OLETF model rat of non-insulin dependent diabetes mellitus (NIDDM) has found significant combinations of marker loci with respect to oral glucose tolerance (OGT).



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Niddm40Rattype 2 diabetes mellitus  QTM  RGD 
Niddm41Rattype 2 diabetes mellitus  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Niddm40Ratimpaired glucose tolerance  IDA  RGD 
Niddm41Ratimpaired glucose tolerance  IDA  RGD 
Objects Annotated

QTLs
Niddm40  (Non-insulin dependent diabetes mellitus QTL 40)
Niddm41  (Non-insulin dependent diabetes mellitus QTL 41)

Strains
F344/NRrrc  (NA)
OLETF  (Otsuka Long-Evans Tokushima fatty)


Additional Information