RGD Reference Report - Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension. - Rat Genome Database

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Detection and positional cloning of blood pressure quantitative trait loci: is it possible? Identifying the genes for genetic hypertension.

Authors: Rapp, JP  Deng, AY 
Citation: Rapp JP and Deng AY, Hypertension 1995 Jun;25(6):1121-8.
RGD ID: 619639
Pubmed: (View Article at PubMed) PMID:7768551

Identification of the quantitative trait loci that influence blood pressure and cause genetic hypertension is a major challenge. Several genetically hypertensive rat strains exist and can be used to locate by linkage analysis broad chromosomal regions containing blood pressure quantitative trait loci. Such broad chromosomal regions, and the narrower subregions, can be moved among strains (ie, production of congenic strains and congenic substrains) to identify small chromosomal regions containing the blood pressure quantitative trait loci. However, ultimate positional cloning of the quantitative trait loci presents a major difficulty because the genetic variants involved are likely to result in subtle changes in function rather than the blatant loss of function characteristic of all mendelian disease genes discovered so far by positional cloning.

Annotation

Disease Annotations    
hypertension  (IAGP)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp10  (Blood pressure QTL 10)

Objects referenced in this article
QTL Bp16 Blood pressure QTL 16 Rattus norvegicus
Strain SS/Jr Salt Sensitive Rattus norvegicus
Strain WKY null Rattus norvegicus

Additional Information