RGD Reference Report - Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. - Rat Genome Database

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Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.

Authors: Kreutz, R  Hubner, N  James, MR  Bihoreau, MT  Gauguier, D  Lathrop, GM  Ganten, D  Lindpaintner, K 
Citation: Kreutz R, etal., Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8778-82.
RGD ID: 619633
Pubmed: PMID:7568016   (View Abstract at PubMed)
PMCID: PMC41050   (View Article at PubMed Central)

We have previously identified a locus on rat chromosome 10 as carrying a major hypertension gene, BP/SP-1. The 100:1 odds support interval for this gene extended over a 35-centimorgan (cM) region of the chromosome that included the angiotensin I-converting enzyme (ACE) locus as demonstrated in a cross between the stroke-prone spontaneously hypertensive rat (SHRSPHD) and the normotensive Wistar-Kyoto (WKY-0HD) rat. Here we report on the further characterization of BP/SP-1, using a congenic strain, WKY-1HD. WKY-1HD animals carry a 6-cM chromosomal fragment genotypically identical with SHRSPHD on chromosome 10, 26 cM away from the ACE locus. Higher blood pressures in the WKY-1HD strain compared with the WKY-0HD strain, as well as absence of linkage of the chromosome 10 region to blood pressure in an F2 (WKY-1HD x SHRSPHD) population suggested the existence of a quantitative trait locus, termed BP/SP-1a, that lies within the SHRSP-congenic region in WKY-1HD. Linkage analysis in the F2 (WKY-0HD x SHRSPHD) cross revealed that BP/SP-1a is linked to basal blood pressure, whereas a second locus on chromosome 10, termed BP/SP-1b, that maps closer to the ACE locus cosegregates predominantly with blood pressure after exposure to excess dietary NaCl. Thus, we hypothesize that the previously reported effect of BP/SP-1 represents a composite phenotype that can be dissected into at least two specific components on the basis of linkage data and congenic experimentation. One of the loci identified, BP/SP-1a, represents the most precisely mapped locus affecting blood pressure that has so far been characterized by random-marker genome screening.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp133Rathypertension  IAGP  RGD 
Bp134Rathypertension  IAGP  RGD 

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Objects Annotated

QTLs
Bp133  (Blood pressure QTL 133)
Bp134  (Blood pressure QTL 134)

Objects referenced in this article
Strain SHRSP Spontaneously Hypertensive Rat, Stroke Prone Rattus norvegicus
Strain SHRSP/Bbb null Rattus norvegicus
Strain WKY/Bbb null Rattus norvegicus

Additional Information