RGD Reference Report - Chromosomal mapping of quantitative trait loci that influence renal hemodynamic functions. - Rat Genome Database

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Chromosomal mapping of quantitative trait loci that influence renal hemodynamic functions.

Authors: Iwai, N  Kinoshita, M  Shimoike, H 
Citation: Iwai N, etal., Circulation 1999 Nov 2;100(18):1923-9.
RGD ID: 619628
Pubmed: PMID:10545438   (View Abstract at PubMed)

BACKGROUND:Impaired renal hemodynamic function has been suspected to be responsible for hypertension in the spontaneously hypertensive rat (SHR). METHODS AND RESULTS:We measured renal hemodynamic functions, including the glomerular filtration rate, renal plasma flow, and renal vascular resistance, in an F2 rat population derived from spontaneously hypertensive and Wistar-Kyoto (WKY) rats and performed a genome-wide screening to map quantitative trait loci that influence these functions to gain insight into the relationship between renal hemodynamic functions and blood pressure control. The D1 Mit7 locus was identified as a major locus that influenced renal hemodynamic functions, and we transferred the SHR chromosomal segment around the D1 Mit7 locus into the WKY strain. The congenic rats exhibited impaired renal hemodynamic functions. The systolic blood pressure of the congenic rats was significantly higher than that of age-matched WKY rats, but only at nighttime. No significant differences in systolic blood pressure during daytime or diastolic blood pressure were observed between the 2 strains. CONCLUSIONS: We have identified a chromosome segment that influences renal hemodynamic function. The SHR chromosome segment around the D1 Mit7 locus had significant, but not dramatic, effects in increasing blood pressure in the WKY genetic background. However, further studies will be necessary to determine the significance of this locus in SHR hypertension.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
kidney disease  IDA 619628 RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased renal glomerular filtration rate  QTM 619628 RGD 
decreased renal plasma flow rate  QTM 619628 RGD 
increased renal vascular resistance  QTM 619628 RGD 

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Objects Annotated

QTLs
Rf51  (Renal function QTL 51)

Strains
SHR  (Spontaneously Hypertensive Rat)
WKY  (NA)

Objects referenced in this article
Strain WKY.SHR-(D1Mgh14-D1Rat77)/Iwai null Rattus norvegicus
Strain WKY.SHR-(D1Rat90-D1Mit18)/Iwai null Rattus norvegicus

Additional Information