RGD Reference Report - Evidence for linkage between essential hypertension and a putative locus on human chromosome 17. - Rat Genome Database

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Evidence for linkage between essential hypertension and a putative locus on human chromosome 17.

Authors: Baima, J  Nicolaou, M  Schwartz, F  DeStefano, AL  Manolis, A  Gavras, I  Laffer, C  Elijovich, F  Farrer, L  Baldwin, CT  Gavras, H 
Citation: Baima J, etal., Hypertension 1999 Jul;34(1):4-7.
RGD ID: 619621
Pubmed: PMID:10406815   (View Abstract at PubMed)

Several clinical and animal studies indicate that essential hypertension is inherited as a multifactorial trait with a significant genetic and environmental component. In the stroke-prone spontaneously hypertensive rat model, investigators have found evidence for linkage to blood pressure regulatory genes (quantitative trait loci) on rat chromosomes 2, 10, and X. In 1 human study of French and UK sib pairs, evidence for linkage has been reported to human chromosome 17q, the syntenic region of the rat chromosome 10 quantitative trait loci (QTL). Our study confirms this linkage (P=0.0005) and refines the location of the blood pressure QTL.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
increased systemic arterial blood pressure  IAGP 619621 RGD 
Objects Annotated

QTLs
Bp132  (Blood pressure QTL 132)


Additional Information