RGD Reference Report - Genetic and correlation analysis of hepatic copper content in the rat. - Rat Genome Database

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Genetic and correlation analysis of hepatic copper content in the rat.

Authors: De Wolf, ID  Fielmich-Bouman, XM  Van Oost, BA  Beynen, AC  Kren, V  Pravenec, M  Van Zutphen, LF  Van Lith, HA 
Citation: de Wolf ID, etal., Biochem Biophys Res Commun 2001 Dec 21;289(5):1247-51.
RGD ID: 619607
Pubmed: PMID:11741328   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.2001.6092   (Journal Full-text)

Thirty recombinant inbred (RI) strains derived from the spontaneous hypertensive rat (SHR/OlaIpcv) and the Brown Norway (BN-Lx/Cub) progenitors were used to search for quantitative trait loci (QTLs) that are responsible for differences in liver copper between these two strains. The heritability of liver copper concentration (expressed as microg/g liver wet wt and microg/g liver dry wt) and liver copper store (microg/whole liver) was estimated to be 57, 57, and 46%, respectively. In a total genome scan of the RI strains, involving over 600 genetic markers, suggestive association was found between liver copper store (microg/whole liver) and the D16Wox9 marker on chromosome 16 (lod score = 2.8), and between liver copper concentration (microg/g dry wt) and the D10Cebrp1016s2 marker on chromosome 10 (lod score = 3.0). These putative QTLs are responsible for nearly 34 and 40% of the additive genetic variability for liver copper store and concentration, respectively.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hcuc1Ratliver disease  IAGP  RGD 
Hcuc2Ratliver disease  IAGP  RGD 
Hcuc1RatWilson disease  IAGP  RGD 
Hcuc2RatWilson disease  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Hcuc1Ratincreased liver copper level  QTM  RGD 
Hcuc2Ratincreased liver copper level  QTM  RGD 
Objects Annotated

QTLs
Hcuc1  (Hepatic copper content QTL 1)
Hcuc2  (Hepatic copper content QTL 2)

Strains
HXB-1-43/Ipcv  (NA)


Additional Information