RGD Reference Report - Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. - Rat Genome Database

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Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.

Authors: Kidd, T  Brose, K  Mitchell, KJ  Fetter, RD  Tessier-Lavigne, M  Goodman, CS  Tear, G 
Citation: Kidd T, etal., Cell 1998 Jan 23;92(2):205-15.
RGD ID: 61733
Pubmed: PMID:9458045   (View Abstract at PubMed)

The robo gene in Drosophila was identified in a large-scale mutant screen for genes that control the decision by axons to cross the CNS midline. In robo mutants, too many axons cross and recross the midline. Here we show that robo encodes an axon guidance receptor that defines a novel subfamily of immunoglobulin superfamily proteins that is highly conserved from fruit flies to mammals. For those axons that never cross the midline, Robo is expressed on their growth cones from the outset; for the majority of axons that do cross the midline, Robo is expressed at high levels on their growth cones only after they cross the midline. Transgenic rescue experiments reveal that Robo can function in a cell-autonomous fashion. Robo appears to function as the gatekeeper controlling midline crossing.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Robo1Rataxon guidance  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Robo1Rataxon guidance receptor activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Robo1  (roundabout guidance receptor 1)

Objects referenced in this article
Gene ROBO2 roundabout guidance receptor 2 Homo sapiens

Additional Information