RGD Reference Report - Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. - Rat Genome Database

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Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.

Authors: Hay, JC  Chao, DS  Kuo, CS  Scheller, RH 
Citation: Hay JC, etal., Cell 1997 Apr 4;89(1):149-58.
RGD ID: 61611
Pubmed: PMID:9094723   (View Abstract at PubMed)

The proposed cis-Golgi vesicle receptor syntaxin 5 was found in a complex with Golgi-associated SNARE of 28 kDa (GOS-28), rbet1, rsly1, and two novel proteins characterized herein: rat sec22b and membrin, both cytoplasmically oriented integral membrane proteins. The complex appears to recapitulate vesicle docking interactions of proteins originating from distinct compartments, since syntaxin 5, rbet1, and GOS-28 localize to Golgi membranes, whereas mouse sec22b and membrin accumulate in the endoplasmic reticulum. Protein interactions in the complex are dramatically rearranged by N-ethylmaleimide-sensitive factor. The complex consists of two or more subcomplexes with some members (rat sec22b and syntaxin 5) in common and others (rbet1 and GOS-28) mutually exclusively associated. We propose that these protein interactions determine vesicle docking/fusion fidelity between the endoplasmic reticulum and Golgi.

Objects referenced in this article
Gene SEC22A SEC22 homolog A, vesicle trafficking protein Homo sapiens
Gene SEC22B SEC22 homolog B, vesicle trafficking protein Homo sapiens
Gene Bet1 Bet1 golgi vesicular membrane trafficking protein Mus musculus
Gene Canx calnexin Mus musculus
Gene Gosr2 golgi SNAP receptor complex member 2 Mus musculus
Gene Sec22b SEC22 homolog B, vesicle trafficking protein Mus musculus
Gene Stx5a syntaxin 5A Mus musculus
Gene Gosr2 golgi SNAP receptor complex member 2 Rattus norvegicus

Additional Information