RGD Reference Report - Inducible expression of cellular retinoic acid-binding protein II in rat ovary: gonadotropin regulation during luteal development. - Rat Genome Database

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Inducible expression of cellular retinoic acid-binding protein II in rat ovary: gonadotropin regulation during luteal development.

Authors: Bucco, RA  Melner, MH  Gordon, DS  Leers-Sucheta, S  Ong, DE 
Citation: Bucco RA, etal., Endocrinology 1995 Jun;136(6):2730-40.
RGD ID: 61557
Pubmed: PMID:7750498   (View Abstract at PubMed)
DOI: DOI:10.1210/endo.136.6.7750498   (Journal Full-text)

Two members of the superfamily of small intracellular carrier proteins for lipophilic compounds are cellular retinoic acid-binding protein and cellular retinoic acid-binding protein II [CRABP(II)]. CRABP is found in many adult tissues, whereas CRABP(II) is more restricted and is reported as abundant primarily in skin. Here we report a much greater expression of CRABP(II) in rat corpus luteum than in any other organ/tissue examined, including skin. A rat complementary DNA clone encoding CRABP(II) was isolated and the ovarian expression followed during gonadotropin induction of follicular development in the pseudopregnant rat. The pattern of rat CRABP(II) messenger RNA and protein expression correlated with the appearance of corpora lutea and the rise in progesterone production as the corpora lutea developed, and was similar to the induction of 3 beta-hydroxysteroid dehydrogenase. Immunohistochemical localization revealed that CRABP(II) appeared in luteal cells and was dramatically restricted to their cytoplasmic compartment, with no apparent presence in the nucleus. This suggests that CRABP(II) may be expressed to restrict retinoic acid from occupying nuclear retinoic acid receptors, implying that the differentiation and maintenance of the rat corpus luteum may involve in part a release of certain pathways from retinoid suppression.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Crabp2Ratlipid transport  NAS  RGD 
Crabp2Ratretinoic acid metabolic process  NAS  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Crabp2Ratlipid binding  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crabp2  (cellular retinoic acid binding protein 2)


Additional Information