RGD Reference Report - Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. - Rat Genome Database

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Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.

Authors: Lyford, GL  Yamagata, K  Kaufmann, WE  Barnes, CA  Sanders, LK  Copeland, NG  Gilbert, DJ  Jenkins, NA  Lanahan, AA  Worley, PF 
Citation: Lyford GL, etal., Neuron 1995 Feb;14(2):433-45.
RGD ID: 61538
Pubmed: PMID:7857651   (View Abstract at PubMed)

Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG) cDNA that is rapidly induced in neurons by activity in models of adult and developmental plasticity. Both the mRNA and the encoded protein are enriched in neuronal dendrites. Analysis of the deduced amino acid sequence indicates a region of homology with alpha-spectrin, and the full-length protein, prepared by in vitro transcription/translation, coprecipitates with F-actin. Confocal microscopy of the native protein in hippocampal neurons demonstrates that the IEG-encoded protein is enriched in the subplasmalemmal cortex of the cell body and dendrites and thus colocalizes with the actin cytoskeletal matrix. Accordingly, we have termed the gene and encoded protein Arc (activity-regulated cytoskeleton-associated protein). Our observations suggest that Arc may play a role in activity-dependent plasticity of dendrites.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
regulation of neuronal synaptic plasticity  IEP 61538 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
actin cytoskeleton  IDA 61538 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Arc  (activity-regulated cytoskeleton-associated protein)


Additional Information