RGD Reference Report - Identification of rat susceptibility loci for adjuvant-oil-induced arthritis. - Rat Genome Database

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Identification of rat susceptibility loci for adjuvant-oil-induced arthritis.

Authors: Lorentzen, JC  Glaser, A  Jacobsson, L  Galli, J  Fakhrai-Rad, H  Klareskog, L  Luthman, H 
Citation: Lorentzen JC, etal., Proc Natl Acad Sci U S A 1998 May 26;95(11):6383-7
RGD ID: 61087
Pubmed: PMID:9600974   (View Abstract at PubMed)
PMCID: PMC27729   (View Article at PubMed Central)

One intradermal injection of incomplete Freund's adjuvant-oil induces a T cell-mediated inflammatory joint disease in DA rats. Susceptibility genes for oil-induced arthritis (OIA) are located both within and outside the major histocompatibility complex (MHC, Oia1). We have searched for disease-linked non-MHC loci in an F2 intercross between DA rats and MHC-identical but arthritis-resistant LEW.1AV1 rats. A genome-wide scan with microsatellite markers revealed two major chromosome regions that control disease incidence and severity: Oia2 on chromosome 4 (P = 4 x 10(-13)) and Oia3 on chromosome 10 (P = 1 x 10(-6)). All animals homozygous for DA alleles at both loci developed severe arthritis, whereas all those homozygous for LEW.1AV1 alleles were resistant. These results have general implications for situations where nonspecific activation of the immune system (e.g., incomplete Freund's adjuvant-oil) causes inflammation and disease, either alone or in conjunction with specific antigens. They may also provide clues to the etiology of inflammatory diseases in humans, including rheumatoid arthritis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DA/ZtmKiniRatExperimental Arthritis MODEL: inducedIAGPFreund's incomplete adjuvantcompared to LEW.1AV1/Kini controlRGD 
LEW.1AV1/KiniRatExperimental Arthritis MODEL: controlIAGPFreund's incomplete adjuvantcompared to DA/ZtmKiniRGD 
Oia2RatExperimental Arthritis  IAGP  RGD 
Oia3RatExperimental Arthritis  IDA  RGD 
DA/ZtmKiniRatrheumatoid arthritis MODEL: inducedIAGPpristane or squalene or type II collagen and Freund's incomplete adjuvant or Freund's complete adjuvantcompared to control strain PVG.1AV1/KiniRGD 
LEW.1AV1.DA-(D10Rat92-D10Rat135)/UbcRatrheumatoid arthritis inducedIAGPFreund's incomplete adjuvantcompared to LEW.1AV1/KiniRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
LEW.1AV1.DA-(D10Rat92-D10Rat135)/UbcRatincreased inflammatory response inducedIAGPFreund's incomplete adjuvantcompared to LEW.1AV1/KiniRGD 
DA/ZtmKiniRatjoint swelling susceptibilityIAGPFreund's incomplete adjuvant RGD 
Oia2Ratjoint swelling  IAGP  RGD 
Oia3Ratjoint swelling  QTM  RGD 
Objects Annotated

QTLs
Oia2  (Oil induced arthritis QTL 2)
Oia3  (Oil induced arthritis QTL 3)

Objects referenced in this article
Marker D10Mgh1 D10Mgh1 Rattus norvegicus
Marker D4Mgh10 D4Mgh10 Rattus norvegicus
QTL Cia13 Collagen induced arthritis QTL 13 Rattus norvegicus
QTL Cia3 Collagen induced arthritis QTL 3 Rattus norvegicus
Strain LEW Lewis Rattus norvegicus
QTL Pia7 Pristane induced arthritis QTL 7 Rattus norvegicus

Additional Information