RGD Reference Report - Two genes in the rat homologous to human NKG2. - Rat Genome Database

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Two genes in the rat homologous to human NKG2.

Authors: Berg, SF  Dissen, E  Westgaard, IH  Fossum, S 
Citation: Berg SF, etal., Eur J Immunol 1998 Feb;28(2):444-50
RGD ID: 61084
Pubmed: (View Article at PubMed) PMID:9521051
DOI: Full-text: DOI:10.1002/(SICI)1521-4141(199802)28:02<444::AID-IMMU444>3.0.CO;2-M

Two different lectin-like receptors for MHC class I molecules have so far been identified on natural killer (NK) cells, the Ly-49 homodimeric receptors in mice and the NKG2/CD94 heterodimeric receptors in humans. The recent identification of a rat CD94 orthologue implied that NK cell receptors equivalent to NKG2/CD94 also exist in rodents. Here we describe the cDNA cloning of two rat genes homologous to members of the human NKG2 multigene family. The deduced rat NKG2A protein contains a cytoplasmic immunoreceptor tyrosine-based inhibition motif (ITIM), whereas the cytoplasmic tail of rat NKG2C lacks ITIM. The genes map to the rat NK gene complex and are selectively expressed by NK cells. The expression is strain dependent, with high expression in DA and low in PVG NK cells, correlating with the expression of rat CD94. Ly-49 genes have previously been identified in the rat, and the existence of rat NKG2 genes in addition to a CD94 orthologue suggests that NK cell populations utilize different C-type lectin receptors for MHC class I molecules in parallel.



Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Nka1  (Natural killer alloreactivity QTL 1)

Objects referenced in this article
Strain DA DA Rattus norvegicus
Gene Galr1 galanin receptor 1 Rattus norvegicus
Gene Galr2 galanin receptor 2 Rattus norvegicus
Gene Klrc1 killer cell lectin like receptor C1 Rattus norvegicus
Gene Klrc2 killer cell lectin like receptor C2 Rattus norvegicus
Gene Klrc3 killer cell lectin like receptor C3 Rattus norvegicus
Strain PVG PVG Rattus norvegicus

Additional Information