RGD Reference Report - Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus. - Rat Genome Database

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Genetic dissection of "OLETF", a rat model for non-insulin-dependent diabetes mellitus.

Authors: Kanemoto, N  Ishigaki H, H  Miyakita, A  Oga, K  Okuno, S  Tsuji, A  Akagi T, T  Takahashi, E  Nakamura, Y  Watanabe, TK 
Citation: Kanemoto N, etal., Mamm Genome 1998 Jun;9(6):419-25
RGD ID: 61072
Pubmed: PMID:9585427   (View Abstract at PubMed)

To elucidate the genetic factors underlying non-insulin-dependent diabetes mellitus (NIDDM), we performed genome-wide quantitative trait locus (QTL) analysis, using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. The OLETF rat is an excellent animal model of NIDDM because the features of the disease closely resemble human NIDDM. Genetic dissection with two kinds of F2 intercross progeny, from matings between the OLETF rat and non-diabetic control rats F344 or BN, allowed us to identify on Chromosome (Chr) 1 a major QTL associated with features of NIDDM that was common to both crosses. We also mapped two additional significant loci, on Chrs 7 and 14, in the (OLETF x F344)F2 cross alone, and designated these three loci as Diabetes mellitus, OLETF type Dmo 1, Dmo2 and Dmo3 respectively. With regard to suggestive QTLs, we found loci on Chrs 10, 11, and 16 that were common to both crosses, as well as loci on Chrs 5 and 12 in the (OLETF x F344)F2 cross and on Chrs 4 and 13 in the (OLETF x BN)F2 cross. Our results showed that NIDDM in the OLETF rat is polygenic and demonstrated that different genetic backgrounds could affect "fitness" for QTLs and produce different phenotypic effects from the same locus.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cari2Rathyperglycemia  QTM  RGD 
Niddm14Rathyperglycemia  QTM  RGD 
Bw115Rattype 2 diabetes mellitus  IDA  RGD 
Niddm14Rattype 2 diabetes mellitus  IDA  RGD 
Niddm15Rattype 2 diabetes mellitus  IDA  RGD 
OLETFRattype 2 diabetes mellitus MODEL: spontaneousIAGP BN,F344/NRrrc;RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype


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Objects Annotated

QTLs
Bw115  (Body weight QTL 115)
Cari2  (Carrageenan-induced inflammation QTL 2)
Niddm14  (Non-insulin dependent diabetes mellitus QTL 14)
Niddm15  (Non-insulin dependent diabetes mellitus QTL 15)

Strains
BN  (BN)
F344/NRrrc  (NA)
OLETF  (Otsuka Long-Evans Tokushima fatty)

Objects referenced in this article
Marker D7Wox18 D7Wox18 Rattus norvegicus
Marker D14Mit5 D14Mit5 Rattus norvegicus
Marker D1Mit8 D1Mit8 Rattus norvegicus
QTL Niddm50 Non-insulin dependent diabetes mellitus QTL 50 Rattus norvegicus

Additional Information