RGD Reference Report - Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat - Rat Genome Database

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Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat

Authors: Gauguier, D  Froguel, P  Parent, V  Bernard, C  Bihoreau, MT  Portha, B  James, MR  Penicaud, L  Lathrop, M  Ktorza, A 
Citation: Gauguier D, etal., Nat Genet 1996 Jan;12(1):38-43
RGD ID: 61061
Pubmed: (View Article at PubMed) PMID:8528248
DOI: Full-text: DOI:10.1038/ng0196-38

Goto-Kakizaki (GK) rats are a well characterized model for non-insulin dependent diabetes mellitus (NIDDM). We have used a combination of physiological and genetic studies to identify quantitative trait loci (QTLs) responsible for the control of glucose homeostasis and insulin secretion in a F2 cohort bred from spontaneously diabetic GK rats. The genetic dissection of NIDDM allowed us to map up to six independently segregating loci predisposing to hyperglycaemia, glucose intolerance or altered insulin secretion, and a seventh locus implicated in body weight. QTLs implicated in glucose tolerance and adiposity map to the same region of rat chromosome 1, and may indicate the influence of a single locus. Our study demonstrates that distinct combinations of genetic loci are responsible for different physiological characteristics associated with the diabetic phenotype in the GK rat, and it constitutes an important step for directing the search for the genetic factors involved in human NIDDM.

Annotation

Disease Annotations    

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bw17  (Body weight QTL 17)
Niddm10  (Non-insulin dependent diabetes mellitus QTL 10)
Niddm11  (Non-insulin dependent diabetes mellitus QTL 11)
Niddm12  (Non-insulin dependent diabetes mellitus QTL 12)
Niddm7  (Non-insulin dependent diabetes mellitus QTL 7)
Niddm8  (Non-insulin dependent diabetes mellitus QTL 8)
Niddm9  (Non-insulin dependent diabetes mellitus QTL 9)

Objects referenced in this article
Marker D8Wox5 D8Wox5 Rattus norvegicus
Marker D7Wox18 D7Wox18 Rattus norvegicus
Marker D2Wox23 D2Wox23 Rattus norvegicus
Marker D5Pas1 D5Pas1 Rattus norvegicus
Marker D1Wox10 D1Wox10 Rattus norvegicus
Marker D17Wox9 D17Wox9 Rattus norvegicus
Marker D4Wox3 D4Wox3 Rattus norvegicus
Strain BN BN Rattus norvegicus
Strain GK/KyoSwe Goto Kakizaki Rattus norvegicus
Strain GK/Ox null Rattus norvegicus
QTL Niddm1 Non-insulin dependent diabetes mellitus QTL 1 Rattus norvegicus
QTL Niddm2 Non-insulin dependent diabetes mellitus QTL 2 Rattus norvegicus

Additional Information