RGD Reference Report - Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat. - Rat Genome Database
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Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat.

Authors: Kren, V  Pravenec, M  Lu, S  Krenova, D  Wang, JM  Wang, N  Merriouns, T  Wong, A  St. Lezin, E  Lau, D  Szpirer, C  Szpirer, J  Kurtz, TW 
Citation: Kren V, etal., J Clin Invest 1997 Feb 15;99(4):577-81
RGD ID: 61054
Pubmed: (View Article at PubMed) PMID:9045857
DOI: Full-text: DOI:10.1172/JCI119198

The spontaneously hypertensive rat (SHR) is the most widely studied animal model of essential hypertension. Despite > 30 yr of research, the primary genetic lesions responsible for hypertension in the SHR remain undefined. In this report, we describe the construction and hemodynamic characterization of a congenic strain of SHR (SHR-Lx) that carries a defined segment of chromosome 8 from a normotensive strain of Brown-Norway rats (BN-Lx strain). Transfer of this segment of chromosome 8 from the BN-Lx strain onto the SHR background resulted in substantial reductions in systolic and diastolic blood pressure and cardiac mass. Linkage and comparative mapping studies indicate that the transferred chromosome segment contains a number of candidate genes for hypertension, including genes encoding a brain dopamine receptor and a renal epithelial potassium channel. These findings demonstrate that BP regulatory gene(s) exist within the differential chromosome segment trapped in the SHR-Lx congenic strain and that this region of chromosome 8 plays a major role in the hypertension of SHR vs. BN-Lx rats.

Annotation

Disease Annotations    
hypertension  (IAGP)

Phenotype Annotations    
Objects Annotated

QTLs
Bp35  (Blood pressure QTL 35)
Cm81  (Cardiac mass QTL 81)

Objects referenced in this article
0 D8Mit6 D8Mit6 All species
0 BN-Lx null All species
0 Rbp2 retinol binding protein 2 All species
0 SHR.BN-RT1n null All species
0 SHR/Ola null All species

Additional Information