RGD Reference Report - Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats - Rat Genome Database

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Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats

Authors: Hilbert, P  Lindpaintner, K  Beckmann, JS  Serikawa, T  Soubrier, F  Dubay, C  Cartwright, P  De Gouyon, B  Julier, C  Takahasi, S  Et, AL 
Citation: Hilbert P, etal., Nature 1991 Oct 10;353(6344):521-9
RGD ID: 61052
Pubmed: (View Article at PubMed) PMID:1656270
DOI: Full-text: DOI:10.1038/353521a0

The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE). This encodes a key enzyme of the renin-angiotensin system, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.

Annotation

Disease Annotations    
hypertension  (IDA)

Phenotype Annotations    

Mammalian Phenotype
Objects Annotated

QTLs
Bp3  (Blood pressure QTL 3)
Bp4  (Blood pressure QTL 4)

Objects referenced in this article
0 SHRSP Spontaneously Hypertensive Rat, Stroke Prone All species
0 WKY null All species

Additional Information